What Is the Fundamental Difference between Percocet and Roxicet?

Both Roxicet and Percocet are popular brand names for combinations of acetaminophen and oxycodone.

Roxicet vs. Percocet

Both Roxicet and Percocet are popular brand names for combinations of acetaminophen and oxycodone. Acetaminophen is a nonsteroidal anti-inflammatory drug (NSAID) that is safe for consumption, as long as one takes less than 4,000 mg per day – more than that can cause an overdose or lead to liver damage.

Because it is safe and effective, however, it is in many over-the-counter drugs that treat pain, the flu, or colds. Oxycodone is an opioid analgesic, which is a Schedule II substance, per the Drug Enforcement Administration (DEA). It is very effective at treating moderate to severe pain, although the drug can also lead to depressed or stopped breathing (overdose), extreme drowsiness or sleepiness, tolerance, dependence, and addiction.

Differences between Roxicet and Percocet

Both of these substances are intended to treat moderate to severe pain, but not chronic pain. They are typically prescribed to people after an acute injury, like a back injury or broken bone, or surgery, particularly dental surgery. Although these drugs are essentially the same, there are a few minor differences. The main difference involves the amount of both oxycodone and acetaminophen found in Roxicet compared to Percocet.

Roxicet: 5 mg of oxycodone or more and 325 mg of acetaminophen

Percocet: either 2.5 or 5 mg of oxycodone HCl and 325 mg of acetaminophen

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Tips on Taking Prescription Painkillers

Typically, opioid drugs can be taken with or without food. More often, they have warnings regarding substances that should not be consumed with them.

Anti-anxiety medications, some antibiotics and antifungals, other opioid drugs, other sedatives and muscle relaxants, and alcohol can all interact with oxycodone and acetaminophen in negative ways, leading to liver and kidney damage, stomach problems, and potential overdose.

While pain relief is important, physicians must monitor their patients for signs of substance abuse when opioid drugs have been prescribed.

The United States, and much of the world, is suffering from an epidemic of opioid addiction and overdose. Treatment must be made widely available, including medication-assisted treatment (MAT) and evidence-based rehabilitation programs.

If people struggling with prescription narcotics abuse do not receive help, they are at risk of switching to stronger, more dangerous narcotics like heroin when they are no longer able to access their prescriptions.

Lacey has worked for over a decade as a writer, in conjunction with having worked around the world in poor social and economic living conditions to provide sustainability programs through numerous non-profits. Her efforts focus on making a difference in people's lives one small step at a time.